Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
This bad news Nebula genomics its will closed in 4 February 2025
if you take test in Nebula genomics , don't forget to download all information BAM and Fastq
https://www.reddit.com/r/Nebulagenomics/...ry_4_2025/
Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
Posts: 46
Threads: 0
Joined: Apr 2024
Gender: Male
Ethnicity: Ru
Nationality: Ru
Y-DNA (P): I1-Y132166
Y-DNA (M): I1a3
mtDNA (M): U5b2a1b
01-22-2025, 10:32 AM
(This post was last modified: 01-22-2025, 11:00 AM by Geo.)
(01-22-2025, 08:31 AM)Capsian20 Wrote: This bad news Nebula genomics its will closed in 4 February 2025
if you take test in Nebula genomics , don't forget to download all information BAM and Fastq
https://www.reddit.com/r/Nebulagenomics/...ry_4_2025/
They have already deleted fastq files.
It's inappropriate that eternal/lifelong subscription is cancelled and not tranferred automatically to new site.
I wonder who will trust further the company with such customer relation history. RIP nebula
mjaguk, Riverman, JMcB like this post
K36 52%Kivutkalns153, K13 25% North Atlantic, 45% Baltic, MTA 20% Svear
Posts: 496
Threads: 25
Joined: Sep 2023
Gender: Male
Ethnicity: English, Scottish & Irish
Nationality: American
Y-DNA (P): I-FT80630
mtDNA (M): H1e2
01-22-2025, 03:29 PM
(This post was last modified: 01-22-2025, 03:30 PM by JMcB.)
(01-22-2025, 08:31 AM)Capsian20 Wrote: This bad news Nebula genomics its will closed in 4 February 2025
if you take test in Nebula genomics , don't forget to download all information BAM and Fastq
https://www.reddit.com/r/Nebulagenomics/...ry_4_2025/
As someone who inadvertently benefitted from Nebula, by having three Nebula testers show up in the imediate vicinty of my tree. With one of them splitting my surname branch and another splitting a friend’s surname branch. That’s a shame. Is there any information out there about their new company?
Capsian20 and mjaguk like this post
Paper Trail: 42% English, 31.5% Scottish, 12.5% Irish, 6.25% German, 6.25% Sicilian & 1.5% French.
LDNA©: Britain & Ireland: 89.3% (51.5% English, 37.8% Scottish & Irish), N.W. Germanic: 7.8%, Europe South: 2.9% (Southern Italy & Sicily)
BigY 700: I1-Z141 >F2642 >Y3649 >Y7198 (c.349 AD) >Y168300 (c.385 AD) >A13248 (c.868 AD) >A13252 (c.1047 AD) >FT81015 (c.1277 AD) >A13243 (c.1620 AD) >FT80854 (c.1700 AD) >FT80630 (1893 AD).
Posts: 693
Threads: 43
Joined: Aug 2023
Gender: Male
Ethnicity: Colonial American
Nationality: American
Y-DNA (P): R1b-U152 >R-FTA96415
Y-DNA (M): I2-P37 > I-BY77146
mtDNA (M): J1b1a1a
mtDNA (P): H66a
You'd think by now full genome testing would be a commodity and readily available. Pay your $100 and wait a week to download. Nothing magic about it anymore.
Riverman, Geo, JMcB And 1 others like this post
Posts: 693
Threads: 43
Joined: Aug 2023
Gender: Male
Ethnicity: Colonial American
Nationality: American
Y-DNA (P): R1b-U152 >R-FTA96415
Y-DNA (M): I2-P37 > I-BY77146
mtDNA (M): J1b1a1a
mtDNA (P): H66a
(01-22-2025, 03:35 PM)AimSmall Wrote: You'd think by now full genome testing would be a commodity and readily available. Pay your $100 and wait a week to download. Nothing magic about it anymore.
Which might speak to why these businesses are going out of business. No longer viable to charge extreme rates.
Probably be able to insert a USB stick in your system, put a drop of blood on it, and in a couple of hours of crunch time have your full genome sequenced and aligned. Go hold down grandma and prick her. lol
Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
(01-22-2025, 03:29 PM)JMcB Wrote: (01-22-2025, 08:31 AM)Capsian20 Wrote: This bad news Nebula genomics its will closed in 4 February 2025
if you take test in Nebula genomics , don't forget to download all information BAM and Fastq
https://www.reddit.com/r/Nebulagenomics/...ry_4_2025/
As someone who inadvertently benefitted from Nebula, by having three Nebula testers show up in the imediate vicinty of my tree. With one of them splitting my surname branch and another splitting a friend’s surname branch. That’s a shame. Is there any information out there about their new company?
No unfortunatley , there is no information about this new company
Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
Posts: 23
Threads: 2
Joined: Feb 2024
Gender: Male
Y-DNA (P): N-MF207071
(01-22-2025, 04:39 PM)AimSmall Wrote: (01-22-2025, 03:35 PM)AimSmall Wrote: You'd think by now full genome testing would be a commodity and readily available. Pay your $100 and wait a week to download. Nothing magic about it anymore.
Which might speak to why these businesses are going out of business. No longer viable to charge extreme rates.
Probably be able to insert a USB stick in your system, put a drop of blood on it, and in a couple of hours of crunch time have your full genome sequenced and aligned. Go hold down grandma and prick her. lol
I don't think so. I believe the prices all these companies were charging were below cost and being supported by VC capital as a way of expanding user base in the hope of charging for ongoing interpretation the data for health. They now find there isn't a market for that service. There isn't an alternative to the current WGS tech at the lowest price point too.
Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
(01-22-2025, 03:35 PM)AimSmall Wrote: You'd think by now full genome testing would be a commodity and readily available. Pay your $100 and wait a week to download. Nothing magic about it anymore.
hmmm is seems to me it is practically possible can do this but it requires extensive knowledge of genetics in addition to computer science
Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
(01-22-2025, 07:35 PM)ronin92 Wrote: (01-22-2025, 04:39 PM)AimSmall Wrote: (01-22-2025, 03:35 PM)AimSmall Wrote: You'd think by now full genome testing would be a commodity and readily available. Pay your $100 and wait a week to download. Nothing magic about it anymore.
Which might speak to why these businesses are going out of business. No longer viable to charge extreme rates.
Probably be able to insert a USB stick in your system, put a drop of blood on it, and in a couple of hours of crunch time have your full genome sequenced and aligned. Go hold down grandma and prick her. lol
I don't think so. I believe the prices all these companies were charging were below cost and being supported by VC capital as a way of expanding user base in the hope of charging for ongoing interpretation the data for health. They now find there isn't a market for that service. There isn't an alternative to the current WGS tech at the lowest price point too.
Did you mean that WGS is considered a loss for companies more than for individuals, and this might be the reason why FTDNA has not according about WGS yet, sticking only to Y700 and mtFull Sequence instead WGS ?
Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
Posts: 125
Threads: 2
Joined: Nov 2023
Gender: Male
Ethnicity: Designed in Scandinavia,
Nationality: mutated and assembled in Polan
Y-DNA (P): I1/M253
01-22-2025, 08:02 PM
(This post was last modified: 01-22-2025, 08:07 PM by sirdan.)
But FTDNA is doing WGS, but providing different product.
WGS for individuals are loss (or lets say, not such profit). Medical market and B2B are profitable.
Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
01-22-2025, 08:47 PM
(This post was last modified: 01-22-2025, 08:50 PM by Capsian20.)
(01-22-2025, 08:02 PM)sirdan Wrote: But FTDNA is doing WGS, but providing different product.
WGS for individuals are loss (or lets say, not such profit). Medical market and B2B are profitable.
No i saw this Quote about WGS in blogger Explained DNA
This Quote
Quote:Katy said that FamilyTreeDNA is NOT planning to offer a Whole Genome Sequencing (WGS) test anytime soon. So, if you’re holding your breath, please don’t. Based on what Katy did say, WGS is very clearly not a consideration in 2024 and I don’t expect to see it in 2025 either unless something changes drastically in terms of technology AND pricing.
While WGS prices have come down, those consumer tests are NOT scanned at the depth and quality required for advanced tests like the Big Y or even Family Finder. Normally consumer-grade WGS tests are scanned between 2 and 10 times, where the FamilyTreeDNA lab scans up to 30 times in order to obtain a quality read. 30X scans are in the same category as medical or clinical grade whole genome scans. Significantly higher quality scans mean significantly higher prices, too, so WGS isn’t ready for genealogy prime time yet.
Additionally, commercially available WGS tests are returned to the customer “as is,” and you’re left to extract the relevant SNPs and arrange them into files, or find someone else to do that. Not to mention, in order to preserve the integrity of their database, FamilyTreeDNA does not accept Y or mitochondrial DNA uploads.
Recently, I saw two WGS files with a 20-25% no-call rate for the autosomal SNPs required for the Family Finder test. Needless to say, that’s completely unacceptable. Some tools attempt to “fix” that mess by filling in the blanks in the format of either a 23andMe or Ancestry file so you can upload to vendors, but that means you’re receiving VERY unreliable matches.
The reason none of the major four vendors offer WGS testing for genealogists is because it’s not financially feasible nor technologically beneficial. The raw data file alone won’t fit on most home computers. WGS is just not soup yet, and it won’t be for the general consuming public, including relevant tools, for at least a few years.
I’ve had my whole genome sequenced, and trust me, I wish it were feasible now, but it just isn’t.
https://dna-explained.com/category/whole...ncing-wgs/
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Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
Posts: 61
Threads: 0
Joined: Sep 2023
Gender: Undisclosed
Ethnicity: Baltic & Scottish
01-22-2025, 09:53 PM
(This post was last modified: 01-22-2025, 10:04 PM by mjaguk.)
DNA Complete website ( https://dnacomplete.com/about-us/ ) says this:
" DNA Complete is powered by a pioneer in genomics. Our sister company and lab partner Nebula Genomics is trusted by more than 100,000 satisfied customers across more than 130 countries. Our founder, Dr. George Church, has been a leader in personal genomics for decades.....
DNA Complete is powered by Nebula Genomics, a division of ProPhase Labs. ProPhase Labs is a publicly traded, next-generation biotech, genomics, and diagnostics company on a mission to create a healthier world through bold action and the power of insight.
The company operates a state-of-the-art, 30,000-square-foot whole genome sequencing lab facility in the U.S. It is one of the largest whole genome sequencing laboratories in the U.S."
This is what Nebula is saying:
" Important Announcement
Nebula Genomics Membership Transition
Nebula Genomics will soon be shutting down.
But don’t worry - this is the start of something even better. We’re thrilled to introduce
DNA Complete
A next-generation service enhanced with a number of new, cutting-edge features to take your genetic insights further.
Take Action Today: Transition to DNA Complete and continue unlocking the power of your DNA."
JMcB and Capsian20 like this post
Posts: 125
Threads: 2
Joined: Nov 2023
Gender: Male
Ethnicity: Designed in Scandinavia,
Nationality: mutated and assembled in Polan
Y-DNA (P): I1/M253
01-22-2025, 11:34 PM
(This post was last modified: 01-22-2025, 11:41 PM by sirdan.)
(01-22-2025, 08:47 PM)Capsian20 Wrote: (01-22-2025, 08:02 PM)sirdan Wrote: But FTDNA is doing WGS, but providing different product.
WGS for individuals are loss (or lets say, not such profit). Medical market and B2B are profitable.
No i saw this Quote about WGS in blogger Explained DNA
This Quote
Quote:Katy said that FamilyTreeDNA is NOT planning to offer a Whole Genome Sequencing (WGS) test anytime soon. So, if you’re holding your breath, please don’t. Based on what Katy did say, WGS is very clearly not a consideration in 2024 and I don’t expect to see it in 2025 either unless something changes drastically in terms of technology AND pricing.
While WGS prices have come down, those consumer tests are NOT scanned at the depth and quality required for advanced tests like the Big Y or even Family Finder. Normally consumer-grade WGS tests are scanned between 2 and 10 times, where the FamilyTreeDNA lab scans up to 30 times in order to obtain a quality read. 30X scans are in the same category as medical or clinical grade whole genome scans. Significantly higher quality scans mean significantly higher prices, too, so WGS isn’t ready for genealogy prime time yet.
Additionally, commercially available WGS tests are returned to the customer “as is,” and you’re left to extract the relevant SNPs and arrange them into files, or find someone else to do that. Not to mention, in order to preserve the integrity of their database, FamilyTreeDNA does not accept Y or mitochondrial DNA uploads.
Recently, I saw two WGS files with a 20-25% no-call rate for the autosomal SNPs required for the Family Finder test. Needless to say, that’s completely unacceptable. Some tools attempt to “fix” that mess by filling in the blanks in the format of either a 23andMe or Ancestry file so you can upload to vendors, but that means you’re receiving VERY unreliable matches.
The reason none of the major four vendors offer WGS testing for genealogists is because it’s not financially feasible nor technologically beneficial. The raw data file alone won’t fit on most home computers. WGS is just not soup yet, and it won’t be for the general consuming public, including relevant tools, for at least a few years.
I’ve had my whole genome sequenced, and trust me, I wish it were feasible now, but it just isn’t.
https://dna-explained.com/category/whole...ncing-wgs/
Okay, but recently FTDNA has bought another set of new sequencers. They are doing internal simply WGS since long time, and stripping data. However it is true their Y bams has much higher coverage, so to guess they are using some PCR technology. Maybe some different reagents are involved too, I dont know.
Please note that you pay for STR test too which is probably another test over SNP, so you know where the price comes from.
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Posts: 162
Threads: 3
Joined: Feb 2024
(01-22-2025, 09:53 PM)mjaguk Wrote: DNA Complete website ( https://dnacomplete.com/about-us/ ) says this:
"DNA Complete is powered by a pioneer in genomics. Our sister company and lab partner Nebula Genomics is trusted by more than 100,000 satisfied customers across more than 130 countries. Our founder, Dr. George Church, has been a leader in personal genomics for decades.....
DNA Complete is powered by Nebula Genomics, a division of ProPhase Labs. ProPhase Labs is a publicly traded, next-generation biotech, genomics, and diagnostics company on a mission to create a healthier world through bold action and the power of insight.
The company operates a state-of-the-art, 30,000-square-foot whole genome sequencing lab facility in the U.S. It is one of the largest whole genome sequencing laboratories in the U.S."
This is what Nebula is saying:
"Important Announcement
Nebula Genomics Membership Transition
Nebula Genomics will soon be shutting down.
But don’t worry - this is the start of something even better. We’re thrilled to introduce
DNA Complete
A next-generation service enhanced with a number of new, cutting-edge features to take your genetic insights further.
Take Action Today: Transition to DNA Complete and continue unlocking the power of your DNA."
and Will DNA Complete go on Yfull haplogroup transfer?
it seems that WGS labs from America want to cut off genealogic costumers, all WGS labs (Sequencing, Nucleus, DNA Complete) are focused on biomedical research
Capsian20 and mjaguk like this post
Posts: 991
Threads: 92
Joined: Sep 2023
Gender: Male
Ethnicity: Berber
Nationality: North Africa
Y-DNA (P): E-V257(×M81)
mtDNA (M): V
mtDNA (P): L2b
(01-22-2025, 11:37 PM)miquirumba Wrote: (01-22-2025, 09:53 PM)mjaguk Wrote: DNA Complete website ( https://dnacomplete.com/about-us/ ) says this:
"DNA Complete is powered by a pioneer in genomics. Our sister company and lab partner Nebula Genomics is trusted by more than 100,000 satisfied customers across more than 130 countries. Our founder, Dr. George Church, has been a leader in personal genomics for decades.....
DNA Complete is powered by Nebula Genomics, a division of ProPhase Labs. ProPhase Labs is a publicly traded, next-generation biotech, genomics, and diagnostics company on a mission to create a healthier world through bold action and the power of insight.
The company operates a state-of-the-art, 30,000-square-foot whole genome sequencing lab facility in the U.S. It is one of the largest whole genome sequencing laboratories in the U.S."
This is what Nebula is saying:
"Important Announcement
Nebula Genomics Membership Transition
Nebula Genomics will soon be shutting down.
But don’t worry - this is the start of something even better. We’re thrilled to introduce
DNA Complete
A next-generation service enhanced with a number of new, cutting-edge features to take your genetic insights further.
Take Action Today: Transition to DNA Complete and continue unlocking the power of your DNA."
and Will DNA Complete go on Yfull haplogroup transfer?
it seems that WGS labs from America want to cut off genealogic costumers, all WGS labs (Sequencing, Nucleus, DNA Complete) are focused on biomedical research
About Yfull , isn't seems to me this will effect a people was test in Nebula and upload result to Yfull
Target: CapsianWGS_scaled
Distance: 1.2510% / 0.01251049
37.2 Iberomaurusian
36.8 Early_European_Farmer
12.8 Early_Levantine_Farmer
8.0 Steppe_Pastoralist
4.8 SSA
0.4 Iran_Neolithic
FTDNA : 91% North Africa +<2% Bedouin + <2 Southern-Levantinfo + <1 Sephardic Jewish + 3% Malta + 3% Iberian Peninsula
23andME : 100% North Africa
WGS ( Y-DNA and mtDNA)
Y-DNA: E-A30032< A30480 ~1610 CE
mtDNA: V12
|