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Analysis of 3.6 million individuals TL;DR- height: still just additive
#1
https://www.biorxiv.org/content/10.1101/...197v1.full

Analysis of 3.6 million individuals yields minimal evidence of pairwise genetic interactions for height

Quote:Abstract
Adult height is a highly heritable polygenic trait with heritability attributable to thousands of independent variants. Large-scale studies have been able to detect genetic variants with contributions to height in the range of approximately 1.2 millimetre per allele copy on average. Non-additive genetic interactions may, in part, account for the difference between broad-sense and narrow-sense heritability estimates. However, prior studies have failed to identify variants with non-additive effects, possibly due to the lack of statistical power. Leveraging 3.6M individuals of European genetic ancestry in the 23andMe research cohort, we performed a genome-wide analysis study (GWAS) to select 1,063 independent common SNPs associated with height (p-value < 5e-8), and then screened for evidence of non-additive effects by analysing 564,453 models including a pairwise SNP-SNP interaction term. We identified 69 pairwise models with suggestive evidence of SNP-SNP interaction (p-value < 1e-4) and, for each SNP pair, we evaluated a fully saturated model including additive, dominant, and epistatic (additive-by-additive, additive-by-dominance and dominance-by-dominance) terms. We tested for the presence of epistatic interactions by comparing models with and without epistatic terms using a likelihood ratio test. Assuming a strict Bonferroni-corrected threshold of 8.9e-8 (0.05/564,453), we found no evidence of epistatic interactions (Likelihood ratio test (LRT) p-value < 9e-07 for all models). Our analysis rules out the existence of epistatic interactions between alleles of >1% frequency with effect sizes larger than 2.42mm. Our large-scale analysis provides further evidence of the minimal contribution of non-additivity in the genetic architecture of adult human height.
anti-racist on here for kicks and giggles

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― Okabe Rintarou

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― Margaret Mead
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#2
Among the populations of the Eastern Eurasian area, the increase in height is also observed in some populations of the Austronesian islanders…
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#3
(08-18-2024, 12:22 PM)CLTVTE Wrote: Among the populations of the Eastern Eurasian area, the increase in height is also observed in some populations of the Austronesian islanders…

good news, I hope the intellectual indicators will also increase
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#4
On the other hand, more widely distributed genetic variants, which may be associated with the increased human height and, thus, by creating differences in height between different ancient human groups, may have served as the natural grounds for the appearance of the Chinese Pangu giant mythology on the one hand, and Izanagi and Izanami giant sky deity mythology, the mythology of the giant sky deity ancestors of the Mansi, on the other hand, according to the IVPP data, distributed in different Homo Sapiens groups during ancient periods and cannot be treated as originating directly from Europe.
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#5
All I can say is the direct male line in my family grew about 12 inches over 4 generations, each one at least a few inches taller than the previous. The reasons looks entirely to do with diet and living conditions gradually improving. They were all from the same basic genetic stock so that wasnt likely a big contribution. Plus the females were only slightly taller with each generation.
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